PDBe 2yza

X-ray diffraction
3.02Å resolution

Crystal structure of kinase domain of Human 5'-AMP-activated protein kinase alpha-2 subunit mutant (T172D)


Function and Biology Details

Reactions catalysed:
ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate
ATP + a protein = ADP + a phosphoprotein
ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
5'-AMP-activated protein kinase catalytic subunit alpha-2 Chain: A
Molecule details ›
Chain: A
Length: 276 amino acids
Theoretical weight: 31.57 KDa
Source organism: Homo sapiens
Expression system: Cell-free protein synthesis
  • Canonical: P54646 (Residues: 6-279; Coverage: 50%)
Gene names: AMPK, AMPK2, PRKAA2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P21
Unit cell:
a: 39.187Å b: 67.336Å c: 50.651Å
α: 90° β: 91.26° γ: 90°
R R work R free
0.235 0.227 0.308
Expression system: Cell-free protein synthesis