PDBe 2yuq

Solution NMR

Solution structure of the SH3 domain of human Tyrosine-protein kinase ITK/TSK

Source organism: Homo sapiens
Entry authors: Abe H, Miyamoto K, Tochio N, Sato M, Koshiba S, Harada T, Watanabe S, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Tyrosine-protein kinase ITK/TSK Chain: A
Molecule details ›
Chain: A
Length: 85 amino acids
Theoretical weight: 10.01 KDa
Source organism: Homo sapiens
Expression system: cell-free protein synthesis
  • Canonical: Q08881 (Residues: 162-239; Coverage: 13%)
Gene names: EMT, ITK, LYK
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: torsion angle dynamics
Chemical shifts: BMR10211  
Expression system: cell-free protein synthesis