› 2yuq

Solution NMR

Solution structure of the SH3 domain of human Tyrosine-protein kinase ITK/TSK

Released:
DOI: 10.2210/pdb2yuq/pdb
PDB entry 2yuq coloured by chain, ensemble of 20 models, front view.
PDB entry 2yuq coloured by chain, ensemble of 20 models, side view.
PDB entry 2yuq coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Abe H, Miyamoto K, Tochio N, Sato M, Koshiba S, Harada T, Watanabe S, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170703 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ITK/TSK Chain: A
Molecule details ›
Chain: A
Length: 85 amino acids
Theoretical weight: 10.01 KDa
Source organism: Homo sapiens
Expression system: cell-free protein synthesis
UniProt:
  • Canonical: Q08881 (Residues: 162-239; Coverage: 13%)
Gene names: EMT, ITK, LYK
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: cell-free protein synthesis

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