› 2ysm

Solution NMR

Solution structure of the second and third PHD domain from Histone-lysine N-methyltransferase 2C (KMT2C/MLL3)

Released:
DOI: 10.2210/pdb2ysm/pdb
PDB entry 2ysm coloured by chain, ensemble of 20 models, front view.
PDB entry 2ysm coloured by chain, ensemble of 20 models, side view.
PDB entry 2ysm coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Qin XR, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185520 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase 2C Chain: A
Molecule details ›
Chain: A
Length: 111 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: cell-free protein synthesis
UniProt:
  • Canonical: Q8NEZ4 (Residues: 342-439; Coverage: 2%)
Gene names: HALR, KIAA1506, KMT2C, MLL3
Sequence domains: PHD-finger
Structure domains: Zinc/RING finger domain, C3HC4 (zinc finger)

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: cell-free protein synthesis

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