› 2yfe

X-ray diffraction
2Å resolution

Ligand binding domain of human PPAR gamma in complex with amorfrutin 1

Released:
DOI: 10.2210/pdb2yfe/pdb
PDB entry 2yfe coloured by chain, front view.
PDB entry 2yfe coloured by chain, side view.
PDB entry 2yfe coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Amorfrutins are potent antidiabetic dietary natural products.
Weidner C, de Groot JC, Prasad A, Freiwald A, Quedenau C, Kliem M, Witzke A, Kodelja V, Han CT, Giegold S, Baumann M, Klebl B, Siems K, Müller-Kuhrt L, Schürmann A, Schüler R, Pfeiffer AF, Schroeder FC, Büssow K, Sauer S
Proc Natl Acad Sci U S A 109 7257-62 (2012)
PMID: 22509006

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 287 amino acids
Theoretical weight: 32.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37231 (Residues: 223-505; Coverage: 56%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand YFE 2 x YFE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: C2
Unit cell:
a: 92.81Å b: 61.1Å c: 118.22Å
α: 90° β: 102.78° γ: 90°
R-values:
R R work R free
0.207 0.204 0.254
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

33 review citations

Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes.
Soccio et al. (2014)
32 more

6 mentions without citation

Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review.
Wang et al. (2014)
5 more