PDBe 2yac

X-ray diffraction
2.2Å resolution

Crystal structure of Polo-like kinase 1 in complex with NMS-P937

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase PLK1 Chain: A
Molecule details ›
Chain: A
Length: 311 amino acids
Theoretical weight: 35.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P53350 (Residues: 36-345; Coverage: 51%)
Gene names: PLK, PLK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P3221
Unit cell:
a: 66.595Å b: 66.595Å c: 154.035Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.213 0.211 0.255
Expression system: Spodoptera frugiperda