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The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger

Source organism: Homo sapiens
Biochemical function: zinc ion binding
Biological process: proteolysis
Cellular component: extracellular matrix

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EC 3.4.24.23: Matrilysin

Reaction catalysed:
Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
Alternative Name(s):
  • MMP
  • MMP 7
  • Matrin
  • Matrix metalloproteinase 7
  • Matrix metalloproteinase pump 1
  • Metalloproteinase pump-1
  • PUMP
  • PUMP-1
  • PUMP-1 proteinase
  • Putative (or punctuated) metalloproteinase-1
  • Putative metalloproteinase
  • Uterine metalloendopeptidase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00413
Domain description: Matrixin
Occurring in:
  1. Matrilysin
The deposited structure of PDB entry 2y6d contains 1 copy of Pfam domain PF00413 (Matrixin) in Matrilysin. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR021190
Domain description: Peptidase M10A
Occurring in:
  1. Matrilysin
IPR033739
Domain description: Peptidase M10A, catalytic domain
Occurring in:
  1. Matrilysin
IPR001818
Domain description: Peptidase M10, metallopeptidase
Occurring in:
  1. Matrilysin
IPR006026
Domain description: Peptidase, metallopeptidase
Occurring in:
  1. Matrilysin
IPR024079
Domain description: Metallopeptidase, catalytic domain superfamily
Occurring in:
  1. Matrilysin

Structure domain

CATH CATH domain
3.40.390.10
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Collagenase (Catalytic Domain)
Homology: Collagenase (Catalytic Domain)
Occurring in:
  1. Matrilysin
The deposited structure of PDB entry 2y6d contains 1 copy of CATH domain 3.40.390.10 (Collagenase (Catalytic Domain)) in Matrilysin. Showing 1 copy in chain A.

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