PDBe 2y4i

X-ray diffraction
3.46Å resolution

KSR2-MEK1 heterodimer


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Kinase suppressor of Ras 2 Chain: B
Molecule details ›
Chain: B
Length: 319 amino acids
Theoretical weight: 36.8 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: Q6VAB6 (Residues: 634-950; Coverage: 33%)
Gene name: KSR2
Sequence domains: Protein tyrosine kinase
Structure domains:
Dual specificity mitogen-activated protein kinase kinase 1 Chain: C
Molecule details ›
Chain: C
Length: 395 amino acids
Theoretical weight: 43.65 KDa
Source organism: Oryctolagus cuniculus
Expression system: Spodoptera frugiperda
  • Canonical: P29678 (Residues: 1-393; Coverage: 100%)
Gene names: MAP2K1, MEK1, PRKMK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P6122
Unit cell:
a: 130.565Å b: 130.565Å c: 221.005Å
α: 90° β: 90° γ: 120°
R R work R free
0.233 0.23 0.293
Expression system: Spodoptera frugiperda