PDBe 2xzz

X-ray diffraction
2.3Å resolution

Crystal structure of the human transglutaminase 1 beta-barrel domain

Released:
Source organism: Homo sapiens
Entry authors: Vollmar M, Krysztofinska E, Krojer T, Yue WW, Cooper C, Kavanagh K, Allerston C, Chaikuad A, Von Delft F, Arrowsmith CH, Weigelt J, Edwards A, Bountra C, Oppermann U

Function and Biology Details

Reaction catalysed:
Protein glutamine + alkylamine = protein N(5)-alkylglutamine + NH(3). 
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein-glutamine gamma-glutamyltransferase K Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 10.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22735 (Residues: 693-787; Coverage: 12%)
Gene names: KTG, TGM1
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: I432
Unit cell:
a: 115.74Å b: 115.74Å c: 115.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.219 0.267
Expression system: Escherichia coli BL21(DE3)