PDBe 2xyn

X-ray diffraction
2.81Å resolution

HUMAN ABL2 IN COMPLEX WITH AURORA KINASE INHIBITOR VX-680

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Abelson tyrosine-protein kinase 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 292 amino acids
Theoretical weight: 33.54 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P42684 (Residues: 279-546; Coverage: 23%)
Gene names: ABL2, ABLL, ARG
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P3221
Unit cell:
a: 170.5Å b: 170.5Å c: 100.651Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.248 0.246 0.284
Expression system: Trichoplusia ni