PDBe 2xrg

X-ray diffraction
3.2Å resolution

Crystal structure of Autotaxin (ENPP2) in complex with the HA155 boronic acid inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Chain: A
Molecule details ›
Chain: A
Length: 862 amino acids
Theoretical weight: 98.87 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q64610 (Residues: 1-887; Coverage: 97%)
  • Best match: Q64610-2 (Residues: 1-862)
Gene names: Atx, Enpp2, Npps2
Sequence domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 63.995Å b: 90.204Å c: 152.672Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.255
Expression system: Homo sapiens