Function and Biology

Crystal structure of the ternary complex between human T cell receptor, staphylococcal enterotoxin H and human major histocompatibility complex class II

Source organisms:
Biochemical function: toxin activity
Biological process: antigen processing and presentation
Cellular component: MHC class II protein complex

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02876
Domain description: Staphylococcal/Streptococcal toxin, beta-grasp domain
Occurring in:
  1. Enterotoxin type H
1 copy of Pfam domain PF02876 (Staphylococcal/Streptococcal toxin, beta-grasp domain) in Enterotoxin type H in PDB 2xn9.

PF09291
Domain description: Domain of unknown function (DUF1968)
Occurring in:
  1. T-cell receptor alpha chain C region
1 copy of Pfam domain PF09291 (Domain of unknown function (DUF1968)) in T-cell receptor alpha chain C region in PDB 2xn9.

PF00969
Domain description: Class II histocompatibility antigen, beta domain
Occurring in:
  1. HLA class II histocompatibility antigen, DRB1-1 beta chain
1 copy of Pfam domain PF00969 (Class II histocompatibility antigen, beta domain) in HLA class II histocompatibility antigen, DRB1-1 beta chain in PDB 2xn9.

PF00993
Domain description: Class II histocompatibility antigen, alpha domain
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
1 copy of Pfam domain PF00993 (Class II histocompatibility antigen, alpha domain) in HLA class II histocompatibility antigen, DR alpha chain in PDB 2xn9.

PF01123
Domain description: Staphylococcal/Streptococcal toxin, OB-fold domain
Occurring in:
  1. Enterotoxin type H
1 copy of Pfam domain PF01123 (Staphylococcal/Streptococcal toxin, OB-fold domain) in Enterotoxin type H in PDB 2xn9.

InterPro InterPro annotations
IPR013307
Domain description: Superantigen, staphylococcal/streptococcal toxin, bacterial
Occurring in:
  1. Enterotoxin type H
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. T-cell receptor alpha chain C region
  2. T-cell receptor beta-1 chain C region
IPR000353
Domain description: MHC class II, beta chain, N-terminal
Occurring in:
  1. HLA class II histocompatibility antigen, DRB1-1 beta chain
IPR006177
Domain description: Staphylococcal/streptococcal toxin, bacterial
Occurring in:
  1. Enterotoxin type H
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1-1 beta chain
IPR001003
Domain description: MHC class II, alpha chain, N-terminal
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
IPR014745
Domain description: MHC class II, alpha/beta chain, N-terminal
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1-1 beta chain
IPR011162
Domain description: MHC classes I/II-like antigen recognition protein
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1-1 beta chain
IPR015370
Domain description: T-cell receptor alpha chain, constant domain
Occurring in:
  1. T-cell receptor alpha chain C region
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. T-cell receptor alpha chain C region
  2. T-cell receptor beta-1 chain C region
IPR006126
Domain description: Staphylococcal enterotoxin/Streptococcal pyrogenic exotoxin, conserved site
Occurring in:
  1. Enterotoxin type H
IPR006173
Domain description: Staphylococcal/Streptococcal toxin, OB-fold
Occurring in:
  1. Enterotoxin type H
IPR006123
Domain description: Staphylococcal/Streptococcal toxin, beta-grasp domain
Occurring in:
  1. Enterotoxin type H
IPR008992
Domain description: Enterotoxin
Occurring in:
  1. Enterotoxin type H
IPR016091
Domain description: Superantigen toxin, C-terminal
Occurring in:
  1. Enterotoxin type H

Structure domains

CATH CATH domains
2.60.40.10
4 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in T-cell receptor beta-1 chain C region in PDB 2xn9.
2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in T-cell receptor alpha chain C region in PDB 2xn9.
6 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class II histocompatibility antigen, DRB1-1 beta chain in PDB 2xn9.
5 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in HLA class II histocompatibility antigen, DR alpha chain in PDB 2xn9.
3.10.20.120
Class: Alpha Beta
Architecture: Roll
Topology: Ubiquitin-like (UB roll)
Homology: Ubiquitin-like (UB roll)
Occurring in:
  1. Enterotoxin type H
1 copy of CATH domain 3.10.20.120 (Ubiquitin-like (UB roll)) in Enterotoxin type H in PDB 2xn9.
3.10.320.10
Class: Alpha Beta
Architecture: Roll
Topology: Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1
Homology: Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1
Occurring in:
  1. HLA class II histocompatibility antigen, DR alpha chain
  2. HLA class II histocompatibility antigen, DRB1-1 beta chain
2 copies of CATH domain 3.10.320.10 (Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1) in HLA class II histocompatibility antigen, DRB1-1 beta chain in PDB 2xn9.
1 copy of CATH domain 3.10.320.10 (Class II Histocompatibility Antigen, M Beta Chain; Chain B, domain 1) in HLA class II histocompatibility antigen, DR alpha chain in PDB 2xn9.
2.40.50.110
Class: Mainly Beta
Architecture: Beta Barrel
Topology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Homology: OB fold (Dihydrolipoamide Acetyltransferase, E2P)
Occurring in:
  1. Enterotoxin type H
1 copy of CATH domain 2.40.50.110 (OB fold (Dihydrolipoamide Acetyltransferase, E2P)) in Enterotoxin type H in PDB 2xn9.