Structure analysis

Crystal structure of the ternary complex between human T cell receptor, staphylococcal enterotoxin H and human major histocompatibility complex class II

X-ray diffraction
2.3Å resolution
Assembly composition:
hetero hexamer (preferred)
Entry contents: 6 distinct polypeptide molecules

Assemblies

Assembly 1 (preferred)
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Multimeric state: hetero hexamer
Accessible surface area: 46900 Å2
Buried surface area: 15400 Å2
Dissociation area: 750 Å2
Dissociation energy (ΔGdiss): -3 kcal/mol
Dissociation entropy (TΔSdiss): 14 kcal/mol
Interface energy (ΔGint): -94 kcal/mol
Symmetry number: 1

Macromolecules

Chain: F
Length: 13 amino acids
Theoretical weight: 1.51 KDa
Source organism: Influenza A virus
Expression system: Not provided
UniProt:
  • Canonical: Q03909 (Residues: 327-339; Coverage: 2%)
Gene name: HA

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Chain: A
Length: 204 amino acids
Theoretical weight: 22.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01848 (Residues: 1-95; Coverage: 67%)
Gene names: TCRA, TRAC
Pfam: Domain of unknown function (DUF1968)
InterPro:
CATH: Immunoglobulins

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Chain: B
Length: 244 amino acids
Theoretical weight: 27.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01850 (Residues: 1-130; Coverage: 73%)
Gene name: TRBC1
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins

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