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Structure of Nek2 bound to aminopyrazine compound 14

X-ray diffraction
2.5Å resolution
PDB entry 2xkc coloured by chain, front view.
PDB entry 2xkc coloured by chain, side view.
PDB entry 2xkc coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase Nek2
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Multimeric state: monomeric
Accessible surface area: 12919.33 Å2
Buried surface area: 516.89 Å2
Dissociation area: 49.06 Å2
Dissociation energy (ΔGdiss): 6.62 kcal/mol
Dissociation entropy (TΔSdiss): -0.83 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-156438

Macromolecules

Serine/threonine-protein kinase Nek2
Chain: A
Length: 279 amino acids
Theoretical weight: 32.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P51955 (Residues: 1-271; Coverage: 61%)
Gene names: NEK2, NEK2A, NLK1
Pfam: Protein kinase domain
InterPro:
CATH:
Serine/threonine-protein kinase Nek2 in PDB entry 2xkc, assembly 1, front view.
Serine/threonine-protein kinase Nek2 in PDB entry 2xkc, assembly 1, side view.
Serine/threonine-protein kinase Nek2 in PDB entry 2xkc, assembly 1, top view.
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