PDBe 2xiy

X-ray diffraction
2.2Å resolution

Protein kinase Pim-1 in complex with fragment-2 from crystallographic fragment screen

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase pim-1 Chain: A
Molecule details ›
Chain: A
Length: 301 amino acids
Theoretical weight: 34.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11309 (Residues: 105-404; Coverage: 74%)
Gene name: PIM1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments


1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.2
Spacegroup: P65
Unit cell:
a: 96.987Å b: 96.987Å c: 80.87Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.172 0.17 0.201
Expression system: Escherichia coli