PDBe 2x9f

X-ray diffraction
1.75Å resolution

ephB4 kinase domain inhibitor complex

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-B receptor 4 Chain: A
Molecule details ›
Chain: A
Length: 302 amino acids
Theoretical weight: 33.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P54760 (Residues: 598-899; Coverage: 31%)
Gene names: EPHB4, HTK, MYK1, TYRO11
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FRE
Spacegroup: P21
Unit cell:
a: 47.12Å b: 52.479Å c: 61.369Å
α: 90° β: 112.05° γ: 90°
R-values:
R R work R free
0.159 0.157 0.194
Expression system: Spodoptera frugiperda