PDBe 2x7g

X-ray diffraction
2.5Å resolution

Structure of human serine-arginine-rich protein-specific kinase 2 (SRPK2) bound to purvalanol B

Source organism: Homo sapiens
Entry authors: Pike ACW, Savitsky P, Fedorov O, Krojer T, Ugochukwu E, von Delft F, Gileadi O, Edwards A, Arrowsmith CH, Weigelt J, Bountra C, Knapp S

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
SRSF protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 389 amino acids
Theoretical weight: 44.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P78362 (Residues: 50-688; Coverage: 56%)
Gene name: SRPK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P3121
Unit cell:
a: 110.31Å b: 110.31Å c: 90.59Å
α: 90° β: 90° γ: 120°
R R work R free
0.186 0.183 0.249
Expression system: Escherichia coli BL21(DE3)