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Crystal structure of MHC CLass I HLA-A2.1 bound to a Peiodate- cleavable peptide

X-ray diffraction
2.3Å resolution
PDB entry 2x4t coloured by chain, front view.
PDB entry 2x4t coloured by chain, side view.
PDB entry 2x4t coloured by chain, top view.
Source organisms:
Assembly composition:
hetero trimer (preferred)
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1
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Multimeric state: hetero trimer
Accessible surface area: 18526.22 Å2
Buried surface area: 5357.43 Å2
Dissociation area: 841.16 Å2
Dissociation energy (ΔGdiss): 11.06 kcal/mol
Dissociation entropy (TΔSdiss): 7.19 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137656
Assembly 2 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 18767.9 Å2
Buried surface area: 4952.03 Å2
Dissociation area: 799.83 Å2
Dissociation energy (ΔGdiss): 10.5 kcal/mol
Dissociation entropy (TΔSdiss): 7.22 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-137656

Macromolecules

HLA class I histocompatibility antigen, A alpha chain
Chains: A, D
Length: 275 amino acids
Theoretical weight: 31.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Pfam:
InterPro:
CATH:
HLA class I histocompatibility antigen, A alpha chain in PDB entry 2x4t, assembly 2, front view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 2x4t, assembly 2, side view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 2x4t, assembly 2, top view.
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Beta-2-microglobulin
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
Beta-2-microglobulin in PDB entry 2x4t, assembly 2, front view.
Beta-2-microglobulin in PDB entry 2x4t, assembly 2, side view.
Beta-2-microglobulin in PDB entry 2x4t, assembly 2, top view.
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65 kDa phosphoprotein
Chains: C, F
Length: 9 amino acids
Theoretical weight: 963 Da
Source organism: Human betaherpesvirus 5
Expression system: Not provided
UniProt:
  • Canonical: P06725 (Residues: 495-503; Coverage: 2%)
Gene name: UL83
65 kDa phosphoprotein in PDB entry 2x4t, assembly 2, front view.
65 kDa phosphoprotein in PDB entry 2x4t, assembly 2, side view.
65 kDa phosphoprotein in PDB entry 2x4t, assembly 2, top view.
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