PDBe 2x4f

X-ray diffraction
2.67Å resolution

The Crystal Structure of the human myosin light chain kinase LOC340156.

Released:
Source organism: Homo sapiens
Entry authors: Muniz JRC, Mahajan P, Rellos P, Fedorov O, Shrestha B, Wang J, Elkins JM, Daga N, Cocking R, Chaikuad A, Krojer T, Ugochukwu E, Yue W, von Delft F, Arrowsmith CH, Edwards AM, Weigelt J, Bountra C, Gileadi O, Knapp S

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Myosin light chain kinase family member 4 Chains: A, B
Molecule details ›
Chains: A, B
Length: 373 amino acids
Theoretical weight: 42.5 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q86YV6 (Residues: 40-388; Coverage: 90%)
Gene names: MYLK4, SGK085
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: C2
Unit cell:
a: 148.88Å b: 70.65Å c: 96.57Å
α: 90° β: 118.96° γ: 90°
R-values:
R R work R free
0.193 0.19 0.241
Expression system: Spodoptera frugiperda