PDBe 2wu6

X-ray diffraction
1.92Å resolution

Crystal Structure of the Human CLK3 in complex with DKI


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Dual specificity protein kinase CLK3 Chain: A
Molecule details ›
Chain: A
Length: 381 amino acids
Theoretical weight: 44.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P49761 (Residues: 254-264, 265-632; Coverage: 59%)
Gene name: CLK3
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 89.15Å b: 62.33Å c: 74.15Å
α: 90° β: 96.04° γ: 90°
R R work R free
0.172 0.17 0.211
Expression system: Escherichia coli BL21(DE3)