› 2wr4

X-ray diffraction
2.5Å resolution

structure of influenza H2 duck Ontario hemagglutinin with human receptor

Released:
DOI: 10.2210/pdb2wr4/pdb
PDB entry 2wr4 coloured by chain, front view.
PDB entry 2wr4 coloured by chain, side view.
PDB entry 2wr4 coloured by chain, top view.
Source organism: unidentified influenza virus
Primary publication:
Structures of receptor complexes formed by hemagglutinins from the Asian Influenza pandemic of 1957.
Liu J, Stevens DJ, Haire LF, Walker PA, Coombs PJ, Russell RJ, Gamblin SJ, Skehel JJ
Proc Natl Acad Sci U S A 106 17175-80 (2009)
PMID: 19805083

Function and Biology Details

Reaction catalysed: 
N-acetyl-O-acetylneuraminate + H(2)O = N-acetylneuraminate + acetate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-112061 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Hemagglutinin-esterase-fusion glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 507 amino acids
Theoretical weight: 57.35 KDa
Source organism: unidentified influenza virus
Expression system: Not provided
UniProt:
  • Canonical: D0VWP9 (Residues: 1-507; Coverage: 100%)
Gene name: HE
Sequence domains: Haemagglutinin
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL, SIA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P212121
Unit cell:
a: 86.78Å b: 150.02Å c: 195.74Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.219 0.255
Expression system: Not provided

Quick links

Citations

29 review citations

Influenza A viruses: new research developments.
Medina et al. (2011)
28 more

3 mentions without citation

New insights into influenza A specificity: an evolution of paradigms.
Ji et al. (2017)
2 more