PDBe 2wnt

X-ray diffraction
2.4Å resolution

Crystal Structure of the Human Ribosomal protein S6 kinase

Released:
Source organism: Homo sapiens
Entry authors: Muniz JRC, Elkins JM, Wang J, Ugochukwu E, Salah E, King O, Picaud S, von Delft F, Bountra C, Arrowsmith CH, Weigelt J, Edwards A, Knapp S

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosomal protein S6 kinase alpha-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 330 amino acids
Theoretical weight: 37.16 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15418 (Residues: 404-719; Coverage: 43%)
Gene names: MAPKAPK1A, RPS6KA1, RSK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P21
Unit cell:
a: 39.66Å b: 142.91Å c: 60.96Å
α: 90° β: 94.9° γ: 90°
R-values:
R R work R free
0.193 0.189 0.24
Expression system: Not provided