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Structural features of native human thymidine phosphorylase and in complex with 5-iodouracil

X-ray diffraction
2.99Å resolution
PDB entry 2wk5 coloured by chain, front view.
PDB entry 2wk5 coloured by chain, side view.
PDB entry 2wk5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1
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Assembly Name: Thymidine phosphorylase
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Multimeric state: monomeric
Accessible surface area: 17030.91 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148809
Assembly 2 (preferred)
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Assembly Name: Thymidine phosphorylase
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Multimeric state: monomeric
Accessible surface area: 17151.43 Å2
Buried surface area: 198.78 Å2
Dissociation area: 99.39 Å2
Dissociation energy (ΔGdiss): 0.09 kcal/mol
Dissociation entropy (TΔSdiss): 0.99 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148809
Assembly 3
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Assembly Name: Thymidine phosphorylase
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Multimeric state: monomeric
Accessible surface area: 16823.52 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148809
Assembly 4
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Assembly Name: Thymidine phosphorylase
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Multimeric state: monomeric
Accessible surface area: 16831.49 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-148809

Macromolecules

Thymidine phosphorylase
Chains: A, B, C, D
Length: 482 amino acids
Theoretical weight: 50 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P19971 (Residues: 1-482; Coverage: 100%)
Gene names: ECGF1, TYMP
Pfam:
InterPro:
CATH:
Thymidine phosphorylase in PDB entry 2wk5, assembly 2, front view.
Thymidine phosphorylase in PDB entry 2wk5, assembly 2, side view.
Thymidine phosphorylase in PDB entry 2wk5, assembly 2, top view.
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