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Crystal structure of the complex between human hedgehog-interacting protein HIP and desert hedgehog without calcium

X-ray diffraction
2.6Å resolution
PDB entry 2wg3 coloured by chain, front view.
PDB entry 2wg3 coloured by chain, side view.
PDB entry 2wg3 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Desert hedgehog protein N-product and Hedgehog-interacting protein
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Multimeric state: hetero dimer
Accessible surface area: 26318.26 Å2
Buried surface area: 2861.07 Å2
Dissociation area: 965.86 Å2
Dissociation energy (ΔGdiss): 10.21 kcal/mol
Dissociation entropy (TΔSdiss): 12.52 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-128899
Assembly 2
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Assembly Name: Desert hedgehog protein N-product and Hedgehog-interacting protein
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Multimeric state: hetero dimer
Accessible surface area: 25614.99 Å2
Buried surface area: 2614.76 Å2
Dissociation area: 779.55 Å2
Dissociation energy (ΔGdiss): 8.95 kcal/mol
Dissociation entropy (TΔSdiss): 12.3 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-128899

Macromolecules

Desert hedgehog protein N-product
Chains: A, B
Length: 164 amino acids
Theoretical weight: 18.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43323 (Residues: 40-194; Coverage: 41%)
Gene name: DHH
Pfam: Hedgehog amino-terminal signalling domain
InterPro:
CATH: Muramoyl-pentapeptide Carboxypeptidase; domain 2
Desert hedgehog protein N-product in PDB entry 2wg3, assembly 1, front view.
Desert hedgehog protein N-product in PDB entry 2wg3, assembly 1, side view.
Desert hedgehog protein N-product in PDB entry 2wg3, assembly 1, top view.
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Hedgehog-interacting protein
Chains: C, D
Length: 463 amino acids
Theoretical weight: 51.8 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q96QV1 (Residues: 214-672; Coverage: 67%)
Gene names: HHIP, HIP, UNQ5825/PRO19644
Pfam:
InterPro:
CATH: Laminin
Hedgehog-interacting protein in PDB entry 2wg3, assembly 1, front view.
Hedgehog-interacting protein in PDB entry 2wg3, assembly 1, side view.
Hedgehog-interacting protein in PDB entry 2wg3, assembly 1, top view.
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