PDBe 2wd1

X-ray diffraction
2Å resolution

Human c-Met Kinase in complex with azaindole inhibitor


Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Hepatocyte growth factor receptor Chain: A
Molecule details ›
Chain: A
Length: 292 amino acids
Theoretical weight: 33.05 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
  • Canonical: P08581 (Residues: 1055-1346; Coverage: 21%)
Gene name: MET
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 37.411Å b: 42.312Å c: 84.826Å
α: 90° β: 93.01° γ: 90°
R R work R free
0.212 0.21 0.265
Expression system: Spodoptera frugiperda