PDBe 2w9z

X-ray diffraction
2.45Å resolution

Crystal Structure of CDK4 in complex with a D-type cyclin

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
G1/S-specific cyclin-D1 Chain: A
Molecule details ›
Chain: A
Length: 257 amino acids
Theoretical weight: 29.28 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24385 (Residues: 16-271; Coverage: 87%)
Gene names: BCL1, CCND1, PRAD1
Sequence domains: Cyclin, N-terminal domain
Structure domains: Cyclin A; domain 1
Cyclin-dependent kinase 4 Chain: B
Molecule details ›
Chain: B
Length: 306 amino acids
Theoretical weight: 34.54 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11802 (Residues: 1-303; Coverage: 99%)
  • Best match: P11802-2 (Residues: 1-183)
Gene name: CDK4
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 57.198Å b: 65.011Å c: 188.699Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.228 0.225 0.272
Expression system: Spodoptera frugiperda