PDBe 2w9f

X-ray diffraction
2.85Å resolution

Crystal Structure of CDK4 in complex with a D-type cyclin

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
G1/S-specific cyclin-D1 Chain: A
Molecule details ›
Chain: A
Length: 271 amino acids
Theoretical weight: 30.99 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24385 (Residues: 1-271; Coverage: 92%)
Gene names: BCL1, CCND1, PRAD1
Sequence domains: Cyclin, N-terminal domain
Structure domains: Cyclin A; domain 1
Cyclin-dependent kinase 4 Chain: B
Molecule details ›
Chain: B
Length: 306 amino acids
Theoretical weight: 34.62 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11802 (Residues: 1-303; Coverage: 99%)
  • Best match: P11802-2 (Residues: 1-183)
Gene name: CDK4
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 58Å b: 64.277Å c: 187.617Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.225 0.3
Expression system: Spodoptera frugiperda