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RU486 bound to the progesterone receptor in a destabilized agonistic conformation

X-ray diffraction
1.8Å resolution
PDB entry 2w8y coloured by chain, front view.
PDB entry 2w8y coloured by chain, side view.
PDB entry 2w8y coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Progesterone receptor
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-139037
Assembly 2
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Assembly Name: Progesterone receptor
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Multimeric state: monomeric
PDBe Complex ID: PDB-CPX-139037

Macromolecules

Progesterone receptor
Chains: A, B
Length: 260 amino acids
Theoretical weight: 29.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06401 (Residues: 678-933; Coverage: 27%)
Gene names: NR3C3, PGR
Pfam: Ligand-binding domain of nuclear hormone receptor
InterPro:
CATH: Retinoid X Receptor
Progesterone receptor in PDB entry 2w8y, assembly 1, front view.
Progesterone receptor in PDB entry 2w8y, assembly 1, side view.
Progesterone receptor in PDB entry 2w8y, assembly 1, top view.
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