PDBe 2w2j

X-ray diffraction
1.6Å resolution

Crystal structure of the human carbonic anhydrase related protein VIII

Released:

Function and Biology Details

Reaction catalysed:
H(2)CO(3) = CO(2) + H(2)O. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carbonic anhydrase-related protein Chain: A
Molecule details ›
Chain: A
Length: 291 amino acids
Theoretical weight: 33.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35219 (Residues: 1-290; Coverage: 100%)
Gene names: CA8, CALS
Sequence domains: Eukaryotic-type carbonic anhydrase
Structure domains: Carbonic Anhydrase II

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 44.267Å b: 73.854Å c: 87.908Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.201 0.199 0.229
Expression system: Escherichia coli BL21(DE3)