› › Structure analysis

Mona SH3C in complex

X-ray diffraction
1.9Å resolution
PDB entry 2w10 coloured by chain, front view.
PDB entry 2w10 coloured by chain, side view.
PDB entry 2w10 coloured by chain, top view.
Source organism: Mus musculus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 23 and GRB2-related adaptor protein 2
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Multimeric state: hetero dimer
Accessible surface area: 4815.32 Å2
Buried surface area: 1334.53 Å2
Dissociation area: 624.39 Å2
Dissociation energy (ΔGdiss): 4.8 kcal/mol
Dissociation entropy (TΔSdiss): 7.58 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131613
Assembly 2
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Assembly Name: Tyrosine-protein phosphatase non-receptor type 23 and GRB2-related adaptor protein 2
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Multimeric state: hetero dimer
Accessible surface area: 4782.81 Å2
Buried surface area: 1250.85 Å2
Dissociation area: 533.04 Å2
Dissociation energy (ΔGdiss): 0.15 kcal/mol
Dissociation entropy (TΔSdiss): 7.06 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-131613

Macromolecules

GRB2-related adaptor protein 2
Chains: A, B
Length: 62 amino acids
Theoretical weight: 7.09 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: O89100 (Residues: 263-322; Coverage: 19%)
Gene names: Gads, Grap2, Grb2l, Grid, Mona
Pfam: SH3 domain
InterPro:
CATH: SH3 Domains
GRB2-related adaptor protein 2 in PDB entry 2w10, assembly 1, front view.
GRB2-related adaptor protein 2 in PDB entry 2w10, assembly 1, side view.
GRB2-related adaptor protein 2 in PDB entry 2w10, assembly 1, top view.
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Tyrosine-protein phosphatase non-receptor type 23
Chains: C, D
Length: 12 amino acids
Theoretical weight: 1.29 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: Q6PB44 (Residues: 719-730; Coverage: 1%)
Gene names: Kiaa1471, Ptpn23
Tyrosine-protein phosphatase non-receptor type 23 in PDB entry 2w10, assembly 1, front view.
Tyrosine-protein phosphatase non-receptor type 23 in PDB entry 2w10, assembly 1, side view.
Tyrosine-protein phosphatase non-receptor type 23 in PDB entry 2w10, assembly 1, top view.
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