PDBe 2w10

X-ray diffraction
1.9Å resolution

Mona SH3C in complex


Function and Biology Details

Reaction catalysed:
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
GRB2-related adaptor protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 62 amino acids
Theoretical weight: 7.09 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
  • Canonical: O89100 (Residues: 263-322; Coverage: 19%)
Gene names: Gads, Grap2, Grb2l, Grid, Mona
Sequence domains: SH3 domain
Structure domains: SH3 Domains
Tyrosine-protein phosphatase non-receptor type 23 Chains: C, D
Molecule details ›
Chains: C, D
Length: 12 amino acids
Theoretical weight: 1.29 KDa
Source organism: Mus musculus
Expression system: Not provided
  • Canonical: Q6PB44 (Residues: 719-730; Coverage: 1%)
Gene names: Kiaa1471, Ptpn23

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P1
Unit cell:
a: 26.137Å b: 34.367Å c: 36.22Å
α: 81.08° β: 87.05° γ: 72.55°
R R work R free
0.164 0.161 0.231
Expression systems:
  • Escherichia coli
  • Not provided