PDBe 2vz9

X-ray diffraction
3.3Å resolution

Crystal Structure of Mammalian Fatty Acid Synthase in complex with NADP

Source organism: Sus scrofa
Primary publication:
The crystal structure of a mammalian fatty acid synthase.
Science 321 1315-22 (2008)
PMID: 18772430

Function and Biology Details

Reaction catalysed:
Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+). 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P21
Unit cell:
a: 96.15Å b: 244.89Å c: 135.37Å
α: 90° β: 101.84° γ: 90°
R R work R free
0.193 0.193 0.244