› 2vxy

X-ray diffraction
1.7Å resolution

The structure of FTsZ from Bacillus subtilis at 1.7A resolution

Released:
DOI: 10.2210/pdb2vxy/pdb
PDB entry 2vxy coloured by chain, front view.
PDB entry 2vxy coloured by chain, side view.
PDB entry 2vxy coloured by chain, top view.
Source organism: Bacillus subtilis
Primary publication:
An inhibitor of FtsZ with potent and selective anti-staphylococcal activity.
Haydon DJ, Stokes NR, Ure R, Galbraith G, Bennett JM, Brown DR, Baker PJ, Barynin VV, Rice DW, Sedelnikova SE, Heal JR, Sheridan JM, Aiwale ST, Chauhan PK, Srivastava A, Taneja A, Collins I, Errington J, Czaplewski LG
Science 321 1673-5 (2008)
PMID: 18801997

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148192 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell division protein FtsZ Chain: A
Molecule details ›
Chain: A
Length: 382 amino acids
Theoretical weight: 40.4 KDa
Source organism: Bacillus subtilis
Expression system: Escherichia coli
UniProt:
  • Canonical: P17865 (Residues: 1-382; Coverage: 100%)
Gene names: BSU15290, ftsZ
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CIT 1 x CIT
Ligand K 1 x K
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P3221
Unit cell:
a: 87.17Å b: 87.17Å c: 89.46Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.186 0.184 0.218
Expression system: Escherichia coli

Quick links

Citations

59 review citations

Challenges of antibacterial discovery.
Silver LL. (2011)
58 more

17 mentions without citation

The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation.
Andreu et al. (2010)
16 more