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ephB4 kinase domain inhibitor complex

X-ray diffraction
1.65Å resolution
PDB entry 2vwz coloured by chain, front view.
PDB entry 2vwz coloured by chain, side view.
PDB entry 2vwz coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Ephrin type-B receptor 4
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Multimeric state: monomeric
Accessible surface area: 12965.08 Å2
Buried surface area: 334.17 Å2
Dissociation area: 41.7 Å2
Dissociation energy (ΔGdiss): 5.83 kcal/mol
Dissociation entropy (TΔSdiss): -1.47 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-157090

Macromolecules

Ephrin type-B receptor 4
Chain: A
Length: 302 amino acids
Theoretical weight: 33.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P54760 (Residues: 598-899; Coverage: 31%)
Gene names: EPHB4, HTK, MYK1, TYRO11
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Ephrin type-B receptor 4 in PDB entry 2vwz, assembly 1, front view.
Ephrin type-B receptor 4 in PDB entry 2vwz, assembly 1, side view.
Ephrin type-B receptor 4 in PDB entry 2vwz, assembly 1, top view.
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