PDBe 2vwv

X-ray diffraction
1.9Å resolution

ephB4 kinase domain inhibitor complex

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ephrin type-B receptor 4 Chain: A
Molecule details ›
Chain: A
Length: 302 amino acids
Theoretical weight: 33.93 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P54760 (Residues: 598-899; Coverage: 31%)
Gene names: EPHB4, HTK, MYK1, TYRO11
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007
Spacegroup: P21
Unit cell:
a: 47.154Å b: 52.872Å c: 57.09Å
α: 90° β: 110.06° γ: 90°
R-values:
R R work R free
0.241 0.238 0.287
Expression system: Spodoptera frugiperda