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Structure of Aurora B kinase in complex with ZM447439

X-ray diffraction
1.86Å resolution
PDB entry 2vrx coloured by chain, front view.
PDB entry 2vrx coloured by chain, side view.
PDB entry 2vrx coloured by chain, top view.
Source organism: Xenopus laevis
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Aurora kinase B-A and Inner centromere protein A
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Multimeric state: hetero dimer
Accessible surface area: 15434.66 Å2
Buried surface area: 3464.39 Å2
Dissociation area: 1,732.19 Å2
Dissociation energy (ΔGdiss): 21.89 kcal/mol
Dissociation entropy (TΔSdiss): 11.12 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126740
Assembly 2
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Assembly Name: Aurora kinase B-A and Inner centromere protein A
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Multimeric state: hetero dimer
Accessible surface area: 15830.8 Å2
Buried surface area: 3452.41 Å2
Dissociation area: 1,726.2 Å2
Dissociation energy (ΔGdiss): 19.27 kcal/mol
Dissociation entropy (TΔSdiss): 11.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-126740

Macromolecules

Aurora kinase B-A
Chains: A, B
Length: 285 amino acids
Theoretical weight: 33.65 KDa
Source organism: Xenopus laevis
UniProt:
  • Canonical: Q6DE08 (Residues: 77-361; Coverage: 79%)
Gene names: airk2-a, aurkb-a
Pfam: Protein kinase domain
InterPro:
CATH:
Aurora kinase B-A in PDB entry 2vrx, assembly 1, front view.
Aurora kinase B-A in PDB entry 2vrx, assembly 1, side view.
Aurora kinase B-A in PDB entry 2vrx, assembly 1, top view.
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Inner centromere protein A
Chains: C, D
Length: 43 amino acids
Theoretical weight: 4.98 KDa
Source organism: Xenopus laevis
UniProt:
  • Canonical: O13024 (Residues: 798-840; Coverage: 5%)
Gene name: incenp-a
Pfam: Inner centromere protein, ARK binding region
InterPro: Inner centromere protein, ARK-binding domain
CATH: Single alpha-helices involved in coiled-coils or other helix-helix interfaces
Inner centromere protein A in PDB entry 2vrx, assembly 1, front view.
Inner centromere protein A in PDB entry 2vrx, assembly 1, side view.
Inner centromere protein A in PDB entry 2vrx, assembly 1, top view.
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