PDBe 2vre

X-ray diffraction
1.95Å resolution

crystal structure of human peroxisomal delta3,5,delta2,4-dienoyl coa isomerase

Released:
Source organism: Homo sapiens
Entry authors: Yue W, Guo K, Von Delft F, Pilka E, Murray J, Roos A, Kochan G, Bountra C, Arrowsmith C, Wikstrom M, Edwards A, Oppermann U

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 296 amino acids
Theoretical weight: 32.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13011 (Residues: 39-49, 50-322; Coverage: 87%)
Gene name: ECH1
Sequence domains: Enoyl-CoA hydratase/isomerase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2221
Unit cell:
a: 127.58Å b: 137.253Å c: 96.137Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.167 0.202
Expression system: Escherichia coli BL21(DE3)