PDBe 2vn1

X-ray diffraction
2.35Å resolution

Crystal structure of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with FK506

Released:

Function and Biology Details

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidylprolyl isomerase Chains: A, B
Molecule details ›
Chains: A, B
Length: 129 amino acids
Theoretical weight: 14.53 KDa
Source organism: Plasmodium falciparum 3D7
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8I4V8 (Residues: 1-127; Coverage: 42%)
Gene names: FKBP35, PF3D7_1247400, PFL2275c
Sequence domains: FKBP-type peptidyl-prolyl cis-trans isomerase

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P43212
Unit cell:
a: 63.064Å b: 63.064Å c: 167.99Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.194 0.25
Expression system: Escherichia coli BL21(DE3)