› 2vk3

X-ray diffraction
1.7Å resolution

Crystal structure of rat profilin 2a

Released:
DOI: 10.2210/pdb2vk3/pdb
PDB entry 2vk3 coloured by chain, front view.
PDB entry 2vk3 coloured by chain, side view.
PDB entry 2vk3 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure, modifications and ligand-binding properties of rat profilin 2a.
Haikarainen T, Chen WQ, Lubec G, Kursula P
Acta Crystallogr D Biol Crystallogr 65 303-11 (2009)
PMID: 19307711

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190151 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Profilin-2 Chain: A
Molecule details ›
Chain: A
Length: 142 amino acids
Theoretical weight: 15.16 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9EPC6 (Residues: 1-140; Coverage: 100%)
Gene name: Pfn2
Sequence domains: Profilin
Structure domains: Dynein light chain 2a, cytoplasmic

Ligands and Environments

3 bound ligands:
Ligand DTU 2 x DTU
Ligand GOL 2 x GOL
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7A
Spacegroup: P41
Unit cell:
a: 51.1Å b: 51.1Å c: 67.52Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.216
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Profilin Isoforms in Health and Disease - All the Same but Different.
Murk et al. (2021)
3 other articles

2 mentions without citation

Structural, Functional, and Immunological Characterization of Profilin Panallergens Amb a 8, Art v 4, and Bet v 2.
Offermann et al. (2016)
1 more