PDBe 2vhs

X-ray diffraction
1.5Å resolution

Cathsilicatein, a chimera


Function and Biology Details

Reaction catalysed:
Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity toward protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Cathepsin L1 heavy chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 217 amino acids
Theoretical weight: 23.72 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
  • Canonical: P07711 (Residues: 114-333; Coverage: 69%)
Gene names: CTSL, CTSL1
Structure domains: Cysteine proteinases

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P1
Unit cell:
a: 56.826Å b: 58.102Å c: 70.209Å
α: 105.67° β: 104.97° γ: 105.05°
R R work R free
0.19 0.188 0.22
Expression system: Komagataella pastoris