PDBe 2vfa

X-ray diffraction
2.8Å resolution

Crystal structure of a chimera of Plasmodium falciparum and human hypoxanthine-guanine phosphoribosyl transferases


Function and Biology Details

Reactions catalysed:
IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
XMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + xanthine
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Hypoxanthine-guanine phosphoribosyltransferase; Hypoxanthine-guanine-xanthine phosphoribosyltransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 229 amino acids
Theoretical weight: 25.83 KDa
Source organisms: Expression system: Escherichia coli
  • Canonical: P00492 (Residues: 51-161; Coverage: 51%)
  • Canonical: P20035 (Residues: 1-58, 172-231; Coverage: 51%)
  • nullnull
Gene names: HPRT, HPRT1, LACZ
Structure domains: Rossmann fold

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: I23
Unit cell:
a: 161.811Å b: 161.811Å c: 161.811Å
α: 90° β: 90° γ: 90°
R R work R free
0.233 0.23 0.278
Expression system: Escherichia coli