PDBe 2vde

X-ray diffraction
3.2Å resolution

Crystal Structure of the Open State of TolC Outer Membrane Component of Mutlidrug Efflux Pumps


Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Outer membrane protein TolC Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 460 amino acids
Theoretical weight: 50.62 KDa
Source organism: Escherichia coli K-12
Expression system: Escherichia coli
  • Canonical: P02930 (Residues: 1-450; Coverage: 91%)
Gene names: JW5503, b3035, colE1-i, mtcB, mukA, refI, toc, tolC, weeA
Sequence domains: Outer membrane efflux protein
Structure domains: Outer membrane efflux proteins (OEP)

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P212121
Unit cell:
a: 128.284Å b: 136.176Å c: 136.133Å
α: 90° β: 90° γ: 90°
R R work R free
0.268 0.266 0.315
Expression system: Escherichia coli