› 2vc0

X-ray diffraction
2.5Å resolution

Feast or famine regulatory protein (Rv3291c)from M. tuberculosis complexed with L-Leucine

Released:
DOI: 10.2210/pdb2vc0/pdb
PDB entry 2vc0 coloured by chain, front view.
PDB entry 2vc0 coloured by chain, side view.
PDB entry 2vc0 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis H37Rv
Primary publication:
Mechanistic insights from the crystal structures of a feast/famine regulatory protein from Mycobacterium tuberculosis H37Rv.
Shrivastava T, Ramachandran R
Nucleic Acids Res 35 7324-35 (2007)
PMID: 17962306

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161260 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
HTH asnC-type domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 150 amino acids
Theoretical weight: 16.53 KDa
Source organism: Mycobacterium tuberculosis H37Rv
Expression system: Escherichia coli
UniProt:
  • Canonical: P96896 (Residues: 1-150; Coverage: 100%)
Gene names: MT3390, lrp
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand LEU 1 x LEU
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P42212
Unit cell:
a: 100.875Å b: 100.875Å c: 99.271Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.212 0.257
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Regulatory and pathogenesis roles of Mycobacterium Lrp/AsnC family transcriptional factors.
Deng et al. (2011)
3 more

1 mention without citation

Mechanistic insights from the crystal structures of a feast/famine regulatory protein from Mycobacterium tuberculosis H37Rv.
Shrivastava et al. (2007)