› 2v9s

X-ray diffraction
2Å resolution

Second LRR domain of human Slit2

Released:
DOI: 10.2210/pdb2v9s/pdb
PDB entry 2v9s coloured by chain, front view.
PDB entry 2v9s coloured by chain, side view.
PDB entry 2v9s coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into the Slit-Robo complex.
Morlot C, Thielens NM, Ravelli RB, Hemrika W, Romijn RA, Gros P, Cusack S, McCarthy AA
Proc Natl Acad Sci U S A 104 14923-8 (2007)
PMID: 17848514

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131762 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Slit homolog 2 protein N-product Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 220 amino acids
Theoretical weight: 24.71 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: O94813 (Residues: 271-480; Coverage: 14%)
Gene names: SLIL3, SLIT2
Sequence domains:
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

2 bound ligands:
Ligand GOL 1 x GOL
Ligand PEG 1 x PEG
1 modified residue:
Ligand CSD 4 x CSD

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 60.36Å b: 123.45Å c: 127.65Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.213 0.261
Expression system: Homo sapiens

Quick links

Citations

28 review citations

Axon guidance molecules in vascular patterning.
Adams et al. (2010)
27 more

3 mentions without citation

Structural insights into the Slit-Robo complex.
Morlot et al. (2007)
2 more