PDBe 2v5p

X-ray diffraction
4.1Å resolution

COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin-like growth factor II Chains: C, D
Molecule details ›
Chains: C, D
Length: 67 amino acids
Theoretical weight: 7.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P01344 (Residues: 25-91; Coverage: 43%)
Gene names: IGF2, PP1446
Sequence domains: Insulin/IGF/Relaxin family
Cation-independent mannose-6-phosphate receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 492 amino acids
Theoretical weight: 54.41 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P11717 (Residues: 1508-1993; Coverage: 20%)
Gene names: IGF2R, MPRI
Sequence domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 165.979Å b: 117.312Å c: 116.668Å
α: 90° β: 123.41° γ: 90°
R-values:
R R work R free
0.293 0.291 0.327
Expression systems:
  • Escherichia coli
  • Cricetulus griseus