PDBe 2v4l

X-ray diffraction
2.5Å resolution

complex of human phosphoinositide 3-kinase catalytic subunit gamma (p110 gamma) with PIK-284


Function and Biology Details

Reactions catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. 
ATP + a protein = ADP + a phosphoprotein. 
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: C2
Unit cell:
a: 144.353Å b: 68.44Å c: 106.619Å
α: 90° β: 95.33° γ: 90°
R R work R free
0.25 0.248 0.296
Expression system: Spodoptera frugiperda