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Structure of a phosphoinositide 3-kinase alpha adaptor-binding domain (ABD) in a complex with the iSH2 domain from p85 alpha

X-ray diffraction
2.4Å resolution
PDB entry 2v1y coloured by chain, front view.
PDB entry 2v1y coloured by chain, side view.
PDB entry 2v1y coloured by chain, top view.
Source organisms:
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Phosphatidylinositol 3-kinase alpha
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Multimeric state: hetero dimer
Accessible surface area: 16369.25 Å2
Buried surface area: 2285.28 Å2
Dissociation area: 1,142.64 Å2
Dissociation energy (ΔGdiss): 7.81 kcal/mol
Dissociation entropy (TΔSdiss): 11.42 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-151132

Macromolecules

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Chain: A
Length: 108 amino acids
Theoretical weight: 12.82 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P32871 (Residues: 1-108; Coverage: 10%)
Gene name: PIK3CA
Pfam: PI3-kinase family, p85-binding domain
InterPro: Phosphatidylinositol 3-kinase, adaptor-binding domain
CATH: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in PDB entry 2v1y, assembly 1, front view.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in PDB entry 2v1y, assembly 1, side view.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform in PDB entry 2v1y, assembly 1, top view.
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Phosphatidylinositol 3-kinase regulatory subunit alpha
Chain: B
Length: 170 amino acids
Theoretical weight: 21.22 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P27986 (Residues: 431-600; Coverage: 24%)
Gene names: GRB1, PIK3R1
Pfam: Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain
InterPro:
CATH: Helix Hairpins
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 2v1y, assembly 1, front view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 2v1y, assembly 1, side view.
Phosphatidylinositol 3-kinase regulatory subunit alpha in PDB entry 2v1y, assembly 1, top view.
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