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PKA structures of indazole-pyridine series of AKT inhibitors

X-ray diffraction
2.5Å resolution
PDB entry 2uzv coloured by chain, front view.
PDB entry 2uzv coloured by chain, side view.
PDB entry 2uzv coloured by chain, top view.
Source organism: Bos taurus
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: cAMP-dependent protein kinase inhibitor alpha and cAMP-dependent protein kinase catalytic subunit alpha
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Multimeric state: hetero dimer
Accessible surface area: 15637.72 Å2
Buried surface area: 3164.12 Å2
Dissociation area: 1,137.39 Å2
Dissociation energy (ΔGdiss): -1.87 kcal/mol
Dissociation entropy (TΔSdiss): 9.17 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-132597

Macromolecules

cAMP-dependent protein kinase inhibitor alpha
Chain: 2
Length: 20 amino acids
Theoretical weight: 2.23 KDa
Source organism: Bos taurus
Expression system: Not provided
UniProt:
  • Canonical: Q3SX13 (Residues: 6-25; Coverage: 26%)
Gene name: PKIA
InterPro: cAMP-dependent protein kinase inhibitor
cAMP-dependent protein kinase inhibitor alpha in PDB entry 2uzv, assembly 1, front view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 2uzv, assembly 1, side view.
cAMP-dependent protein kinase inhibitor alpha in PDB entry 2uzv, assembly 1, top view.
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cAMP-dependent protein kinase catalytic subunit alpha
Chain: A
Length: 336 amino acids
Theoretical weight: 39.22 KDa
Source organism: Bos taurus
Expression system: Escherichia coli
UniProt:
  • Canonical: P00517 (Residues: 16-351; Coverage: 96%)
Gene name: PRKACA
Pfam: Protein kinase domain
InterPro:
CATH:
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 2uzv, assembly 1, front view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 2uzv, assembly 1, side view.
cAMP-dependent protein kinase catalytic subunit alpha in PDB entry 2uzv, assembly 1, top view.
Molecule details ›

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