› 2uxa

X-ray diffraction
2.38Å resolution

Crystal structure of the GluR2-flip ligand binding domain, r/g unedited.

Released:
DOI: 10.2210/pdb2uxa/pdb
PDB entry 2uxa coloured by chain, front view.
PDB entry 2uxa coloured by chain, side view.
PDB entry 2uxa coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Developmentally regulated, combinatorial RNA processing modulates AMPA receptor biogenesis.
Greger IH, Akamine P, Khatri L, Ziff EB
Neuron 51 85-97 (2006)
PMID: 16815334

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148604 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor 2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 261 amino acids
Theoretical weight: 29.21 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P19491 (Residues: 412-795; Coverage: 30%)
Gene names: GluA2, Glur2, Gria2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

2 bound ligands:
Ligand GLU 3 x GLU
Ligand ZN 5 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P21212
Unit cell:
a: 114.254Å b: 164.003Å c: 47.462Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.174 0.265
Expression system: Escherichia coli

Quick links

Citations

21 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
20 more

7 mentions without citation

Gating motions underlie AMPA receptor secretion from the endoplasmic reticulum.
Penn et al. (2008)
6 more