PDBe 2tps

X-ray diffraction
1.25Å resolution

THIAMIN PHOSPHATE SYNTHASE

Released:

Function and Biology Details

Reaction catalysed:
4-amino-2-methyl-5-diphosphomethylpyrimidine + 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate = diphosphate + thiamine phosphate + CO(2)
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thiamine-phosphate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 227 amino acids
Theoretical weight: 24.31 KDa
Source organism: Bacillus subtilis
UniProt:
  • Canonical: P39594 (Residues: 1-222; Coverage: 100%)
Gene names: BSU38290, ipa-26d, thiC, thiE, ywbK
Sequence domains: Thiamine monophosphate synthase
Structure domains: Aldolase class I

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P43212
Unit cell:
a: 76.83Å b: 76.83Å c: 140.1Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 not available 0.222