Function and Biology

TYROSINE HYDROXYLASE CATALYTIC AND TETRAMERIZATION DOMAINS FROM RAT

EC 1.14.16.2: Tyrosine 3-monooxygenase

Reaction catalysed:
L-tyrosine + tetrahydrobiopterin + O(2) = L-dopa + 4a-hydroxytetrahydrobiopterin.
Comments:
  • Activated by phosphorylation, catalyzed by EC 2.7.11.27.
  • The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96.
  • The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.
Systematic name:
L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
Alternative Name(s):
  • L-tyrosine hydroxylase
  • Tyrosine 3-hydroxylase
  • Tyrosine hydroxylase

Sequence family

Pfam Protein family (Pfam)
PF00351
Domain description: Biopterin-dependent aromatic amino acid hydroxylase
Occurring in:
  1. Tyrosine 3-monooxygenase
1 copy of Pfam domain PF00351 (Biopterin-dependent aromatic amino acid hydroxylase) in Tyrosine 3-monooxygenase in PDB 2toh.

InterPro InterPro annotations
IPR019774
Domain description: Aromatic amino acid hydroxylase, C-terminal
Occurring in:
  1. Tyrosine 3-monooxygenase
IPR018301
Domain description: Aromatic amino acid hydroxylase, iron/copper binding site
Occurring in:
  1. Tyrosine 3-monooxygenase
IPR001273
Domain description: Aromatic amino acid hydroxylase
Occurring in:
  1. Tyrosine 3-monooxygenase
IPR036329
Domain description: Aromatic amino acid monoxygenase, C-terminal domain superfamily
Occurring in:
  1. Tyrosine 3-monooxygenase
IPR036951
Domain description: Aromatic amino acid hydroxylase superfamily
Occurring in:
  1. Tyrosine 3-monooxygenase

Structure domain

CATH CATH domain
1.10.800.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Phenylalanine Hydroxylase
Homology: Phenylalanine Hydroxylase
Occurring in:
  1. Tyrosine 3-monooxygenase
1 copy of CATH domain 1.10.800.10 (Phenylalanine Hydroxylase) in Tyrosine 3-monooxygenase in PDB 2toh.
SCOP SCOP annotation
56535
Class: Alpha and beta proteins (a+b)
Fold: Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Superfamily: Aromatic aminoacid monoxygenases, catalytic and oligomerization domains
Occurring in:
  1. Tyrosine 3-monooxygenase
1 copy of SCOP domain 56535 (Aromatic aminoacid monoxygenases, catalytic and oligomerization domains) in Tyrosine 3-monooxygenase in PDB 2toh.